Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-Analysis
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Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-Analysis
BACKGROUND Parkinson disease (PD) is a neurodegenerative process that leads to a selective loss of dopaminergic neurons, mainly in the basal ganglia of the brain. Numerous studies have analyzed the ability of optical coherence tomography (OCT) to detect retinal nerve fiber layer (RNFL) thickness abnormalities and changes in PD, but the results have not always been consistent. Therefore, we carr...
متن کاملRetinal nerve fiber layer thickness in Parkinson disease.
Dopaminergic neuronal cells have been identified in the inner nuclear and inner plexiform layers of the human retina. The dopaminergic content of the retina is reduced in patients with idiopathic Parkinson disease (PD). These observations led us to study the retinal nerve fiber layer (RNFL) thickness in patients with PD without visual impairment compared to healthy controls using spectral-domai...
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Introduction: We investigated correlation between the retinal nerve fiber layer (RNFL) thickness and the severity of Parkinson's disease (PD). Methods: In this study, the RNFL thickness of 23 patients with Parkinson’s disease (PD) was compared to normal controls (NCs). PD severity was assessed by the MDS-UPDRS (movement disorder society Unified Parkinson Disea...
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normal 0 false false false en-us x-none ar-sa background: this study was designed to investigate the effect of vitiligo on the retinal nerve fiber layer (rnfl) thickness. materials and methods: this prospective study was conducted in the department of ophthalmology at kä±rä±kkale university during 2010 and 2011.sixty eight eyes of 34 vitiligo patients were included in the study. eighty four eye...
متن کاملRetinal nerve fiber layer thinning in Parkinson disease
Retinal dopamine loss in Parkinson disease (PD) is reflected by visual neurophysiological dysfunction. We measured the thickness of the circumpapillary retinal nerve fiber layer (RNFL) in PD patients using optical coherence tomography. The thickness in the inferior quadrant of PD patients (147 +/- 20 microns) was significantly thinner than that of controls (173 +/- 12 microns; p=0.002), while t...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0085718